Original Article
Protection against Brain Tissues Oxidative Damage as a Possible Mechanism for Improving Effects of Soy on Scopolamine-Induced Learning and Memory Impairments in Ovariectomized Rats
Author(s):
Sareh Karimi, Mahmoud Hosseini*, Zahra Mahdian and Beheshteh Babazadeh
Background: Modulatory and antioxidant effects of soy extract on the central nervous system have been reported. Aim: The effects of soy on learning and memory impairments induced by scopolamine and the brain tissues oxidative damage was investigated. Materials and Methods: The ovariectomized rats were divided: (1) Ovariectomized (OVX), (2) Ovariectomized – Scopolamine (OVX-Sco), (3) Ovariectomized -Scopolamine - Soy 20 (OVX-Sco-Soy 20) and (4) Ovariectomized -Scopolamine-Soy 60 (OVX-Sco-Soy 60). Soy extract was administered (20 or 60 mg/kg; i.p.) daily for 6 weeks before training in the passive avoidance (PA) test. Sco (2mg/kg) was injected 30 min after training in the PA test. Results: In PA test, the time latency to enter the dark compartment in OVX- Sco group was higher than OVX g.. Read More»
Select your language of interest to view the total content in your interested language
Annals of Medical and Health Sciences Research received 20588 citations as per google scholar report