Saurabh Sharma

Department of Pharmacology, I.S.F College of Pharmacy, Punjab, India

Publications

  • Research Article   
    Effect of Retinoic Acid in Improving Endothelium Dependent Vascular Reactivity in Hyperhomocysteinemic Rats
    Author(s): Shivali Singla*, Sachin Goyal, Raveena Devi, Shalini Jamwal and Saurabh Sharma

    Introduction: Retinoic acid is a metabolite of Vitamin A (retinol) has been reported to activate PI3K/Akt pathway and up regulate NO synthesis that has a beneficial effect in the endothelial cell. Thus, the present study was designed to investigate the effect of retinoic acid in HHcy induced vascular dysfunction. Objective: This study evaluates the protective effect of retinoic acid on L-methionine-induced Hyperhomocysteinemia (HHcy) in rats. Materials and methods: Wistar rats were randomly divided into seven groups as normal control, L-methionine, HHcy+Retinoic acid (2.5 mg/kg/d), HHcy+RA (5 mg/kg/d), HHcy+RA (5 mg/kg/d) + BEZ235 (4 mg/kg/d), HHcy+RA (5 mg/kg/d)+L-NAME (10 mg/kg/d), HHcy+Lisinopril (1 mg/ kg./d). HHcy was induced by oral administration of L-methionine (1.7 g/kg) for 28 days. From the 21st.. Read More»

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