Research Article
Ovarian Response to Letrozole Combined with Gonadotropin Regimen in Patients with Diminished Ovarian Reserve Candidate for IVF
Author(s):
Zahra Heidar, Negar Hamzehpour*, Masoomeh Mirzamoradi, Shahrzad Zadeh Modarres, Malak Nemati and Maryam Roshani
Background: Diminished ovarian reserve (DOR) is characterized by poor fertility outcomes even by using assisted reproductive techniques (ART). Recent data suggests that co-treatment by letrozole may improve ovarian response to FSH in poor responders and reduce gonadotropin dose required for ovarian stimulation. This study aimed to investigate the effect of letrozole administration combined with gonadotropin in patient with decreased ovarian reserve candidate for IVF.
Material and Methods: A clinical trial was conducted in the Infertility clinic, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sixty-nine infertile women with DOR who have poor response to ovarian stimulation by gonadotropin-only regimen were recruited. The patients were treated by letrozole at 7.5 mg/day and FSH at 225 mg/day, started on the 2nd - 3.. Read More»
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