Due to trauma, teeth can have an extensive lesion along with external inflammatory resorption, with no history of pain or mobility, which can be discovered in routine dental examination only. Depends on the case, treatment options of such teeth may vary, and can include both, surgical or nonsurgical approach. Various clinical studies have confirmed that with simple nonsurgical root canal treatment, even large periapical lesions can be treated successfully, if the lesion is in direct communication with the root canal system. Recently, few cases have been published, in which large periapical lesions with external inflammatory resorption has been successfully treated by nonsurgical root canal treatment. This article also reports a case in which a mandibular central incisor with a large periapical lesion and inflammatory root resorption has been treated successfully with nonsurgical endodontic therapy.