I read an article by Zaidi et al. titled to “A study on assessment of mast cell (MCs) in oral squamous cell carcinoma (OSCC)” with great interest. We are concerned about their meandering conclusion presuming close association between OSCC development and MC. Since the role of MCs in the tumor stroma has been very controversial so far, it needs further clarification. Furthermore, my interest in this study is that we have recently demonstrated human MC‑mediated cytotoxicity against different human tumor cells in vitro.[2,3] Here, we want to emphasize anti‑tumor effects of MC in the light of recent literature and our findings as well.
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