From follicle generation to hormone production, and from pregnancy to birth, the circadian system plays an essential role at every level in a woman's life. A woman's menstrual cycle is based on a monthly rhythm and menopause is among the main factors affecting this rhythm. It is important to note that the onset of menopause is influenced by both epigenetic alterations and changes in circadian rhythm. In this article, we discuss the role of epigenetic alterations in regulating the circadian gene network as well as the consequences of deteriorating circadian rhythms in menopause. Here, we provide evidence of how these findings can change the age of menopause, whether it is by the deterioration of circadian rhythms or by observing the epigenetic alterations that are taking place.