Biochemical Markers of Oxidative Stress in Patients with Inflammatory Bowel Diseases

Author(s): Grazyna Mierzwa, Maria Klopocka, Daria Kupczyk and Beata Augustynska*

Background: Inflammatory Bowel Diseases (IBD) is a group of diseases of unexplained etiology, characterized by periods of remissions and exacerbations. Reactive Oxygen Species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in upraise of IBD. The aim of our study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease.

 

Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) of Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was a material for biochemical analysis: HT, GSH, GPXp, GPXRBC, GST, GR, SOD-1, MDA, NO2 -/NO3 - and CP.

Results: There were statistically significant differences in oxidative stress parameters observed between study group and control group, especially concerning HT, GSH, GPXRBC, GST, SOD-1, MDA and NO2 -/NO3 .

Discussion: The assumption that increased activity of antioxidative compounds may constitute a defense against the influence of oxidative stress may be true. Their decreased activity may participate in lowering organism abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies as far as targeted preventive strategies are needed.


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