AMHSR

Clinical Evaluation for the Thrombopoietic Activity of Platenza Tablet in Cases of Dengue with Thrombocytopenia - Randomized Open Label Comparative Clinical Study

Author(s): Srikrishna HA*, Rahul Anand, Zorin puii, Archana Singh, Ankit Kumar, Gaurav Kumar, Manjunathswamy Hiremath, Israrul Haque, Pankaj Hans, Das JKL and Anjana Bulusu

Introduction: Dengue is one of the vector borne viral infections growing across various countries. Despite the availability of various therapeutic agents, a potentially safe and efficacious herbal formulation is of high need. Objective: To evaluate the safety and efficacy of platenza tablets in increasing the platelet counts in cases of dengue fever associated with thrombocytopenia. Method: This study was conducted at Patna Medical College and Hospital, the Department of Medicine, Bihar. It was a randomized open label controlled comparative clinical study. Forty subjects were taken up for the study and grouped into platenza group (n=21) and standard comparator group (n=19) where platenza group received platenza tablets at a dose of two tablets twice daily oral and standard comparator received Carica papaya leaves extract at a dose of one tablet three times daily for a period of 10 days. Results: Platelet count was monitored at screening, and on each day from Day 1 to Day 4, Day 6, Day 8 and Day 10. Post 10 days, it was observed that, platenza group showed a potential increase in platelet count from 52905 to 207381 cells/mm3 compared to that of the standard comparator group. There were no drop outs in the study. Conclusion: Based on the improvement in subjective and objective parameters; it can be concluded that platenza tablets compared to the Carica papaya leaves extract alone, exhibited a potential Thrombopoietic activity along with the reduction of clinical signs and symptoms of dengue fever associated with thrombocytopenia.


Indexed in

PubMed Central Index Copernicus Emerging Sources
Citation Index
Emerging Sources Citation Index
Abstracted/Indexed in

  • Include Baidu Scholar
  • CNKI (China National Knowledge Infrastructure)
  • EBSCO Publishing's Electronic Databases
  • Exlibris – Primo Central
  • Google Scholar
  • Hinari
  • Infotrieve
  • National Science Library
  • ProQuest
  • TdNet
  • African Index Medicus
Annals of Medical and Health Sciences Research The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal. more >>
Submit your Manuscript