Introduction: Dengue is one of the vector borne viral infections growing across various countries. Despite the availability of various therapeutic agents, a potentially safe and efficacious herbal formulation is of high need. Objective: To evaluate the safety and efficacy of platenza tablets in increasing the platelet counts in cases of dengue fever associated with thrombocytopenia. Method: This study was conducted at Patna Medical College and Hospital, the Department of Medicine, Bihar. It was a randomized open label controlled comparative clinical study. Forty subjects were taken up for the study and grouped into platenza group (n=21) and standard comparator group (n=19) where platenza group received platenza tablets at a dose of two tablets twice daily oral and standard comparator received Carica papaya leaves extract at a dose of one tablet three times daily for a period of 10 days. Results: Platelet count was monitored at screening, and on each day from Day 1 to Day 4, Day 6, Day 8 and Day 10. Post 10 days, it was observed that, platenza group showed a potential increase in platelet count from 52905 to 207381 cells/mm3 compared to that of the standard comparator group. There were no drop outs in the study. Conclusion: Based on the improvement in subjective and objective parameters; it can be concluded that platenza tablets compared to the Carica papaya leaves extract alone, exhibited a potential Thrombopoietic activity along with the reduction of clinical signs and symptoms of dengue fever associated with thrombocytopenia.
Select your language of interest to view the total content in your interested language
Annals of Medical and Health Sciences Research received 20588 citations as per google scholar report
The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.