Introduction: There are evidence of age-related changes in platelet count and function, driven by changes in hematopoietic tissue, the composition of the blood and vascular health. Platelet count remains relatively stable during middle age but falls in elderly people. In this study we had tried to correlate platelet indices with the clinical profile like blood sugar, Lipid profile, blood pressure, Ischemic Heart disease and Chronic Obstructive Pulmonary Disease in elderly patients admitted in rural teaching hospital. Materials and methods: In this study, we have included 1000 patients among them 601 (60.1%) were males and 399 (39.9%) were females with the mean age of 66.02 ± 5.76 years. We studied platelet indices like plateletcrit (PCT), platelet distribution width (PDW) and mean platelet volume (MPV). Observation and results: The platelet indices (PCT, MPV and PDW) showed negative correlation with FBS and it was statistically significant (p<0.05). The platelet indices showed positive correlation with blood pressure, negative with total cholesterol, positive with HDL, negative with LDL, negative with VLDL and negative correlation with TG. The platelet indices had negative correlation with IHD and COPD and they were statistically significant (p<0.05). Conclusion: The platelet indices showed significant correlation with various clinical profiles of the elderly patients and they should be used routinely to aid in diagnosis.