The COVID-19 epidemic has spread rapidly worldwide. It can cause severe lung disease and multiple organ damage. The support of vulnerable individuals during the CIVID-19 pandemic includes those with congenital or acquired immune-depression. Due to long-term use of oral immunosuppressive drugs and associated comorbidities, it is admitted that liver transplant recipients are suspected to be more susceptible to COVID-19 infection and have a worse prognosis than the general population. In this report, we describe two cases of liver transplant recipient with COVID-19 infection. We also reviewed some literature about the characteristics and management of COVID-19 in liver transplant patients.