Background and Objectives: The present meta-analysis and systematic review individually examines each intranet and compare the results of different studies in order to arrive at more comprehensive outcomes. Method: The search took place between 2005 and 2019. In this study, we first reviewed the abstract of the articles and selected the studies that had the most coordination with our goals, and then we examined the entire text and finally, 8 studies were selected. In addition to reviewing the literature, the results are extracted and enter the meta-analyzer stata14, which summarizes the final results. Conclusion: This systematic review and meta-analysis summarizes the effects Bisphosphonates, Fluorides, Corticosteroids and drugs in orthodontic tooth movement (OTM). Corticosteroids affect the rate of OTM, and may also influence the long-term stability of orthodontically moved teeth. Moreover, non-steroidal anti-inflammatory drugs (NSAIDs) effectively alleviate the pain caused by orthodontic treatment, and also affect the movement of teeth by reducing the inflammatory or bone resorption process.