Background: In normal physiology, there is a dynamic equilibrium between reactive oxygen species (ROS), activity and antioxidant defense capacity and when that equilibrium shifts in favor of ROS, oxidative stress results which leads to periodontal diseases. Advanced oxidation protein products (AOPP) are proteins, predominantly albumin and its aggregates which are damaged by oxidative stress. Fluoride ion at molecular level is related to the production of free radicals and an alteration of the antioxidant defense mechanism. So a study was conducted to estimate the salivary levels of AOPP among healthy, chronic periodontitis (CP) subjects and chronic periodontitis subjects with dental fluorosis (CP-F). Methods: Total 90 subjects were selected and divided into three groups based on clinical parameters group I: 30 healthy subjects, group II: 30 C.P subjects, group III: 30 CP-F subjects, Saliva samples were collected and AOPP levels were determined by U V- spectrophotometry at 340 nm. Results: Salivary levels of AOPP were highest among C.P with dental fluorosis compared to C.P and healthy individuals which were statistically significant. Conclusions: Dental fluorosis can act as an adjunct along with AOPP in contemplating it as a diagnostic indicator of oxidative stress in periodontal disease and aid early planning of treatment modalities.