Background: Dysglycemia is a subclinical condition of altered glucose levels (intermediate hyperglycaemia), considered as a high-risk factor for diabetes and cardiovascular diseases. Lifestyle change, including diet and exercise, along with the management of blood glucose levels is the primary prevention of diabetes. Aim: In this clinical study, we investigated the potential role of a nutraceutical compound, based on Mediterranean citrus extracts, in regulating blood glucose in dysglycemic adults. Material and Methods: 40 adults with dysglycemia (100-125 mg/dl) were instructed to take a food supplement based on 460 mg Lemotrin® complex plus 100 µg chromium picolinate, 1 tablet twice a day during main meals for 12 weeks, in addition to general indications of a Mediterranean diet, maintaining overall constant dietary habits. Reduction of blood glucose levels was set as the primary endpoint, while reduction of HOMA index, insulinemia, body weight, abdominal circumference and improvement of the lipid profile as secondary endpoints. Results: After 12 weeks significant reductions of fasting blood glucose (-7.7%), fasting insulin (-31.6%), HOMA-index (-35.73%), glycated hemoglobin (A1c) (-4.78%) levels were observed, with a non-significant body weight reduction. Conclusion: Our findings suggest that the supplementation of the Mediterranean citrus complex improves the glycemic profile in subjects with dysglycemia.