Background: Fibro-osseous lesions comprise a group of disorders characterized histologically by replacement of normal bone by cellular fibrous tissue within which varying amount of predominantly woven bone and acellular islands of mineralized tissue develops. These lesions commonly affect the jaw and craniofacial bones. Identification of the specific entity is crucial due to treatment variations. This study aimed to describe the spectrum, age, sex and morphological pattern of fibro-osseous lesions in Port Harcourt, as well as compare the findings with previous studies done in Nigeria and other parts of the world. Materials and Methods: This was a 7 year retrospective study from 2nd January, 2008 to 31st December, 2014 of all fibro-osseous lesions recorded in the oral pathology/pathology registers of the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. Results: Thirty one cases of fibro-osseous lesions were diagnosed during the seven year study period, with age range from 6–65 years and mean age of 26.7 years. Female to male ratio was 1.8 : 1. Lesions were more frequent in the mandible (51.6%), than maxilla (45.2%) and frontal bone (3.2%). Ossifying fibroma accounted for the vast majority (21 cases, 67.7%) of fibro-osseous lesions distantly followed by fibrous dysplasia (6 cases, 19.4%) and other less frequent types. Conclusion: This study showed that ossifying fibroma was the predominant subtype which was consistent with most published reports in developing world. Due to close architectural structures of these lesions, a definitive diagnosis requires a thorough knowledge and correlation of clinical, radiological and histological findings.