Background: Typhoid fever is transmitted by contaminated food and water and highly endemic in developing countries including India. Widal agglutination test is widely accepted in the diagnosis of typhoid infection based on baseline titre. Objective: This study was aimed to investigate the prevalence and seasonal dynamics of typhoid infection with an exploration of hematological parameters as a diagnostic tool in Raebareli region. Research Methodology: More than nine hundred febrile patients over a period of one year were diagnosed in a tertiary care hospital for Widal agglutination test with dilution ranging from 1:40 to 1:320. In addition, various hematological parameters were also examined based on CBC and microscopy. Results: Typhoid infection was found prevalent in 22.72% of febrile patient’s particularly in females and peaked around the month of April and September during transient and monsoon period in Raebareli region. Low hemoglobin levels were also significantly detected in typhoid patients with normocytic anemia. Conclusion: Typhoid infection is highly prevalent particularly during monsoon and transition period favoring its transmission based on Widal agglutination test. Moreover typhoid patients were found more prone to normocytic hypochromic anemia than other forms.