Mucormycosis is a rare but aggressive fungal infection requiring prompt intervention to prevent life-threatening complications. Non-COVID-related cases continue to present significant challenges in diagnosis and management. A 55-year-old male presented with facial swelling, nasal obstruction, and persistent pain in the maxillary region, significantly impacting his quality of life. Clinical examination and radiological investigations confirmed non-COVID mucormycosis with extensive maxillary involvement. The patient underwent total maxillectomy under general anesthesia to remove necrotic tissue, followed by reconstruction with zygomatic quad implants for functional and aesthetic rehabilitation. The surgical approach achieved successful infection control, with restoration of facial contours and oral function, leading to significant improvement in the patient’s overall well-being. Early diagnosis, aggressive surgical debridement, and advanced implant-based rehabilitation are crucial in managing extensive maxillary defects caused by mucormycosis. A multidisciplinary approach ensures optimal functional and aesthetic outcomes.
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