Carcinoma of unknown primary (CUP) represents a heterogeneous group of metastatic tumors where, even after a complete diagnostic workup the site of origin of the tumor is not detected. The diagnosis of CUP should be made after complete clinical history, physical examination, routine laboratory tests, imaging, and a careful review of the histology, and sometimes radio‑metabolic techniques are also used. CUP accounts for 3-5% of all cancers.
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