Research Article
Analysis of Oxidative Stress in Patients with Breast Cancer and Obesity
Author(s):
Iuliana Pantelimon, Laurentia Nicoleta Gales, Anca Zgura*, Georgia Luiza Serbanescu, Dragos Eugen Georgescu, Irina Nita, Loredana Sabina Cornelia Manolescu, Andra Maria Stancu, Maria Iuliana Gruia, Rodica Maricela Anghel and Dumitru Cristinel Badiu
Background: Breast cancer is a major source of public health concern. Our work aims to study the role of oxidative stress in breast pathophysiology. Materials & Methods: A group of 39 patients diagnosed and treated for breast cancer was followed in a prospective, observational, nonrandomized study to assess the serum oxidative stress levels. Thus, the following parameters were determined: Malondialdehyde (MDA) concentration as a measure of lipid peroxidation reaction, serum thiol concentration as end products of oxidative degradation of proteins, and total level of antioxidants. Results: 81.9% of these patients have an excess of adipose tissue (overweight or obesity). A positive correlation was obtained between the serum peroxides values and obesity as measured by Body Mass Index (BMI) (p<0.01) and waist circumference (p<0.0.. Read More»
10.54608.annalsmedical.2021.9
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