Narendar K

Department of Pharmacology, Al-Ameen Medical College, Vijayapura, Karnataka, India

Publications

  • Original Article   
    Identification of Insulin Sensitizing Activity of Gymnema sylvestre in Dexamethasone Induced Insulin Resistance in Rats
    Author(s): Nagendra Nayak IM, Hemanth Kumar V*, Shobha V Huilgol and Narendar K

    Background: Insulin resistance plays a key role in the onset of several metabolic disorders. Aim and Objectives: To determine the insulin sensitizing property of aqueous extract of Gymnema sylvestre leaves on dexamethasone induced insulin resistance in rats. Materials and Methods: Animals were divided into five groups (n=6) and the study was conducted for a period of 12 days. Insulin resistance was induced with dexamethasone (Dex) (4 mg/kg) intraperitoneal (i.p) injection. Control (Group I) and Dexamethasone group (Group II) received gum acacia orally (p.o) for 12 days. The test groups (Group III and Group IV) received Gymnema sylvestre leaves aqueous extract (1 and 2 gm/kg/p.o. respectively) and standard drug group (Group V) received rosiglitazone (8 mg/kg/p.o) for 12 days. All the groups except control g.. Read More»

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