Tuberculosis of breast is a rare disease usually affecting young women in developing countries. In western countries it occurs most commonly in women of Asian origin. It is usually unilateral. It mimics pyogenic inflammatory disease and carcinoma of the breast. A 18 year old female patient presented with multiple discharging sinuses in left breast and fever for last four months. She had been treated with non-specific antimicrobials by physicians with no response. She neither had previous coexistent evidence of tuberculosis elsewhere in the body nor family history of tuberculosis. Pus was collected from discharging sinuses and subjected to Cartridge Based Nucleic Acid Amplification Test (CBNAAT). It detected Mycobacterium tuberculosis and Rifampicin resistance tuberculosis (RR-TB). Liquid culture and Drug susceptibility testing (LC-DST) confirmed it as a case of multidrug-resistant tuberculosis (MTB isolate Rifampicin and Isoniazid resistant).