Objectives: Caudal epidural steroid injection (CESI) is used frequently in the treatment of patients with chronic lumbar pain and leg. Obesity is one of the main reasons of lumbar pain. In this study of ours we tried to assess the effects of CESI on patients with normal weight, over weight and obese suffering from lumbar pain. Design: Retrospective Study. Settings: Diyarbakır Selahaddin Eyyübi State Hospital. Subjects and methods: Our study is conducted on 300 patients to assess the effects of CESI on whom lumbar and leg pain persisted for three months between January 2015-December 2016. US guidance used for all injections. Groups were allocated as: GroupI: BMI<25 kg/m2, GroupII: BMI>25 kg/m2 and Group III: 30 ≤ BMI<40 kg/m2. Main outcome measures: 130 participants were identified as normal weight, 116 over weight, 54 obese. Pain scores were assessed by using Visual analogue scores (VAS). VAS scores were measured at preinjection, 1st, 3rd, and for a period of 6th months after injection. Life quality was evaluated with Short Form – 36 (SF-36). Results: After injection VAS scores were found lower for all repeated measured times during the six months interval (p<0.05). No statistical differences were found between the groups regarding age or gender. In all groups the number of patients suffering from chronic low back pain was high and the highest score was found in Group III but statically not significant. SF-36 scores were found improved after injection compared to baseline values. Conclusion: CESI is helpful in relieving pain for all patients at all weights and improves the quality of individual’s daily life.