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Trilogy-Function Thiadiazole-Triazole-Pyridine Derivatives as Anticancer Activity


Nasreen R Jber* and Mehdi S Shihab

1-Methyl-4-(6-(subsitutedphenyl)-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazol-3-yl)- alkylpyridinium was synthesized in this study. The 4-Amino-5-pyridin-4-yl-4H-(1,2,4) triazole-3-thiol was combined with substituted phenacyl bromide in a condensation reaction to produce 4-Amino-5-pyridin-4-yl-4H-(1,2,4)triazole-3-thiol. 1-Methyl-4- (6-(substitutedphenyl)-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazol-3-yl)pyridinium was alkylated with three distinct alkyl bromides. The anticancer effects of the produced triazolo (3,4-b)(1,3,4)thaidiazole pyridine derivatives were investigated using FTIR and 1H-NMR, and some compounds in the series showed promising anti-cancer activity when compared to standard medications.

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Annals of Medical and Health Sciences Research The Annals of Medical and Health Sciences Research is a bi-monthly multidisciplinary medical journal.
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