Research Article
Neo Adjuvant Chemotherapy plus Volumetric-Modulated Arc Therapy for the Treatment of Loco Regionally Advanced Nasopharyngeal Carcinoma: A Retrospective Study
Author(s):
Nesrin I Tarbiah*, Reema S Alamri, Nuha A Alkhattabi, Maryam M Alhemadi, Huda S Almutairi, Reem Y Alzahri and Hend Hussain
Background and Purpose: Nasopharyngeal carcinoma is attributed for 33 percent of head and neck malignancy in Saudi Arabia. In treatment of NPC, chemo radiotherapy is used as a modality of choice. The present study aims to determine the effect of Neo Adjuvant Chemotherapy NACT in Local Control LC and Overall Survival OS of NPC patients treated in King Faisal Hospital and Research Center KFSHRC, Jeddah, Saudi Arabia. Materials and Methods: Patients treated for NPC were retrospectively studied. Demographic characteristics and chemotherapy data were collected and analyzed. Kaplan-Meier product-survival estimates and multivariate analysis were conducted to describe and determine the effect of NACT plus CCT in LC and OS. Results: Seventyseven patients with loco regional advanced NPC were studied. Majority of the patients had Stage 3 NPC n=34, 44.2 percent a.. Read More»
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